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Neurontin caps 300 mg per day for a 12-week period.
The trial design was double-blinded. Half the participants received 1 mg/day of capsaicin per day (control group) and half the participants received same dose, but twice a day, as the study therapy (capsaicin for arthritis).
The primary endpoint was percentage change in the number of knee AOA, measured in each of the 2 treatment groups. Other secondary endpoints included pain, function, and physical the use of pain management therapies.
Participants were enrolled from February 1994 through December 1996 in the community by referrals from local physician practices. They completed a baseline evaluation, and randomized participants to 1 of the 2 treatment groups (i.e., capsaicin or placebo in the controlled-trials design).
During the entire 12-week course of study management, participants received a total of 200 mg capsaicin or a placebo daily.
"The results indicate that capsaicin treatment was well tolerated," said James M. Davis, MD, the study's lead author and a professor of medicine at the University Washington and director of the UW Pain & Rheumatology Clinic. "We believe our results reinforce original hypothesis that capsaicin therapy was effective in the treatment of chronic pain, and in all aspects of pain. We are currently evaluating the dose of capsaicin."
"Our study adds to the growing body of data indicating that capsaicin, a peptide present in chili peppers, is effective the treatment of chronic pain and may be an effective therapy for reducing opioid-related complications of cancer pain," said Joseph A. Pashakostas, MD, assistant professor at UW's School of Medicine and Public Health. "There is already anecdotal evidence and clinical data pointing to capsaicin as a promising agent in clinical practice. However, this study is the first to demonstrate how capsaicin therapy affects bone remodeling in osteoarthritis, which is of particular interest for patients with osteoarthritis."
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The study is partially supported by The National Institutes of Health.
The research was partly supported by grant R00GM091240 from the National Cancer Institute. ROME — In a sign of how far Pope Francis has moved in his criticism of capitalism and crusade against inequality, a Vatican committee appointed by the pope is Finasteride tablet price looking at a proposal to allow small group of the richest Catholics to buy their church's properties.
The financial institutions that have developed this plan said it only extends a tax break for small savings, but Mr. Francis's supporters see it as a new opening for his reformist message.
"This proposal will help the church respond to this new reality in the world a way that will help lay the groundwork for a more humane, integrated and democratic society," Cardinal Sean O'Malley, a moderate Francis ally, said in an interview.
If the group agrees to plan, some bishops could end up retaining control of the real estate they own for themselves, instead of selling it to others. That could increase the church's income and, eventually, its central headquarters in the center of capital, Rome, at about 2.
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